Browsing by Author "Arenas, Alex"

Now showing 1 - 7 of 7
  • No Thumbnail Available
    Item
    De-escalating therapy in inflammatory bowel disease: Results from an observational study in clinical practice
    (2024) Arenas, Alex; Moreta, Maria Jose; Ordas, Ingrid; Fernandez-Clotet, Agnes; Caballol, Berta; Gallego, Marta; Vara, Alejandro; Barastegui, Rebeca; Giner, Angel; Prieto, Cristina; Masamunt, Maria Carme; Candia, Roberto; Ricart, Elena
    Background and objectives: Combination therapy with an immunomodulator (IMM) and an antiTNF is commonly recommended in Crohn's disease (CD) and ulcerative colitis (UC) patients. However, little is known about relapse rates after therapeutic de-escalation. This study aimed to evaluate the risk of relapse in a cohort of UC and CD patients with long-standing clinical remission after discontinuation of IMM or anti-TNF and to identify predictive factors for relapse. Methods: This retrospective study included patients with UC or CD on combination therapy and clinical remission for at least 6 months. IMM or anti-TNF was stopped upon physician decision. Primary objective was to evaluate the relapse rates after discontinuation of IMM or anti-TNF and to analyze predictors of relapse. Results: The study included 88 patients, 48 patients (54.5%) discontinued IMM and 40 (45.5%) anti-TNF. During follow-up, relapse rates were 16.7% and 52.5% in the IMM discontinuation group and anti-TNF discontinuation group, respectively (p < 0.001). Multivariate analysis showed that anti-TNF discontinuation (HR = 3.01; 95% CI = 1.22-7.43) and ileal CD location (HR = 2.36; 95% CI = 1.02-5.47) were predictive factors for relapse while inflammatory CD phenotype was a protective factor (HR = 0.32; 95% CI = 0.11-0.90). Reintroduction of anti-TNF upon relapse was effective and safe. Conclusion: Anti TNF discontinuation led to significantly higher relapse rates compared to IMM discontinuation in UC and CD patients on combination therapy. Anti-TNF discontinuation and ileal CD location were identified as predictive factors for relapse while inflammatory CD phenotype was a protective factor. Retreatment after anti-TNF discontinuation was effective and safe. (c) 2023ElsevierEspa na,S.L.U.Allrightsreserved.
  • Thumbnail Image
    Item
    Etiologic and clinical characterization of community acquired gastroenteritis in adult patients in a Chilean emergency room by the FilmArray GI panel
    (2018) Valenzuela Abarca, Eduardo; Legarraga Raddatz, Paulette; Peña Riveros, Arturo Nicolás; Arenas, Alex; Berkowitz Fiebich, Loni; Ramírez, Gigliola; Wozniak Banchero, Aniela; García Cañete, Patricia; Álvarez Lobos, Manuel
  • Thumbnail Image
    Item
    Minimally Invasive Methods for Staging in Lung Cancer : Systematic Review and Meta-Analysis
    (2016) Labarca, Gonzalo; Aravena León, Carlos Andrés; Ortega, Francisco; Arenas, Alex; Majid, Adnan; Folch, Erik; Mehta, Hiren J.; Jantz, Michael A.; Fernandez Bussy, Sebastian
  • Thumbnail Image
    Item
    Pirfenidone for Idiopathic Pulmonary Fibrosis : A Systematic Review and Meta-Analysis
    (2015) Aravena León, Carlos Andrés; Labarca, Gonzalo; Venegas Garrido, Carmen Paz; Arenas, Alex; Rada G., Gabriel
  • No Thumbnail Available
    Item
    Prevalence of Helicobacter pylori Antimicrobial Resistance Among Chilean Patients
    (2021) Gonzalez-Hormazabal, Patricio; Arenas, Alex; Serrano, Carolina; Pizarro, Margarita; Fuentes-Lopez, Eduardo; Arnold, Jorge; Berger, Zoltan; Musleh, Maher; Valladares, Hector; Lanzarini, Enrique; Jara, Lilian; Castro, V. Gonzalo; Camargo, M. Constanza; Riquelme, Arnoldo
    Background. Treatments for Helicobacter pylori (H. pylori) eradication include the use of antibiotics and a proton-pump inhibitor. Antibiotic resistance is a major concern for two drugs: levofloxacin and clarithromycin. The aim was to determine the prevalence of levofloxacin resistance (LevoR) and clarithromycin resistance (ClaR) in an urban population in Santiago, Chile.
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    Vascular malformation simulating a gastric subepithelial lesion: the risks of the bite-on-bite biopsy technique
    (2023) Candia Balboa, Roberto Andres; Arenas, Alex; Chahuan Abde, Javier Nicolas; Riquelme Pizarro, Carlos Rodrigo; Mendez Olivieri, Gonzalo Patricio