Browsing by Author "Aranda, E."

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    2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells
    (2010) Quezada, M.; Diaz, J.; Henriquez, S.; Bravo Castillo, María Loreto; Aranda, E.; Oliva, B.; Villalón, Manuel J.; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Brosens, J. J.; Lange, C. A.; Owen, Gareth Ivor
    2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol with antiangiogenic and antitumor properties, although its mechanisms of action remain unclear. Progestins in hormone replacement therapy increase the risk of breast cancer. Progesteron
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    ACCUMULATION OF 5-HYDROXYTRYPTAMINE BY AGING PLATELETS - STUDIES IN A MODEL OF SUPPRESSED THROMBOPOIESIS IN DOGS
    (GEORG THIEME VERLAG KG, 1994) Aranda, E.; Pizarro, M.; Pereira, J.; Mezzano, D.
    Thrombocytopenia was induced in healthy, male mongrel dogs by intramuscular injection of a single dose of estradiol valerate (1 mg/kg). A steady, almost linear decay of the blood platelet count starting about day 6 post-estradiol and attaining a mean value of 14 x 10(3) platelets/mu l one week later was observed. Thrombocytopenia is explained mainly by suppression of thrombocytopoiesis, as established by two independent ways: 1. Megakaryocytes in the bone marrow were markedly reduced. 2. Kinetic studies with In-111 labeled autologous platelets revealed a nearly linear decay of the radioactivity and mean survival times within the expected range. The progressive reduction in the platelet count is associated with an increase in the mean age of the platelets still circulating. Following estradiol injection, platelet 5-hydroxytryptamine (5-HT) increased from a basal value of 130 +/- 30 ng/10(8) platelets (platelet count of 351 +/- 53 x 10(3) platelets/mu l) to 343 +/- 100 ng/10(8) platelets eleven days latter, when the platelet count dropped to 32 +/- 18 x 10(3) platelets/mu l. No significant changes in the number or affinity of the 5-HT uptake receptors could be demonstrated in platelets exposed in vitro and in vivo to estradiol. Our results indicate that aging platelets accumulate 5-HT, probably by a sustained exposure to the monoamine in plasma, confirming previous observations based on models in which thrombopenia was induced by immune and mechanical means.
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    Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 β-cells
    (2015) Cataldo Bascuñan, Luis Rodrigo; Cortés Mora, Víctor Antonio; Mizgier Rojas, María Luisa; Aranda, E.; Mezzano, Diego; Olmos Coelho, Pablo Roberto; Galgani Fuentes, José; Suazo, J.; Santos Martín, José Luis
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    Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa
    (2014) Lange, S.; Gonzalez, I.; Pinto, M.; Arce, M.; Valenzuela Bassi, Rodrigo Andrés; Aranda, E.; Elliot, M.; Alvarez, M.; Henriquez, S.; Velasquez, Ever A.; Orge, F.; Oliva, B.; Gonzalez, P.; Villalón, Manuel J.; Cautivo Reyes, Kelly Margarita; Kalergis Parra, Alexis Mikes; Pereira, K.; Mendoza, C.; Saez, C.; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Parborell, F.; Irusta, G.; Palma, V.; Allende, M.; Owen, Gareth Ivor
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    Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 beta-Cells Treated with Palmitate and Oleate
    (2016) Cataldo Bascuñan, Luis Rodrigo; Busso, Dolores; Olmos Coelho, Pablo Roberto; Galgani Fuentes, José; Valenzuela, R.; Mezzano, D.; Aranda, E.; Cortés Mora, Víctor Antonio; Santos Martín, José Luis