Browsing by Author "Angulo Troncoso, Jenniffer Alexandra"

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    Infection with SARS-CoV-2 variant Gamma (P.1) in Chile increased ICU admission risk three to five-fold
    (2023) Sauré, Denis; Rizzo, Alessandro; Neira, Ignasi; Goic, Marcel; O’Ryan, Miguel; Torres, Juan P.; Bruhn, Alejandro; Ferres Garrido, Marcela Viviana; Angulo Troncoso, Jenniffer Alexandra; Vera Alarcon, Maria Magdalena; Basso, Leonardo J.
    The 2021 wave of SARS-CoV-2 infection in Chile was characterized by an explosive increase in ICU admissions, which disproportionately affected individuals younger than 60 years. This second wave was also accompanied by an explosive increase in Gamma (P.1) variant detections and the massive vaccine rollout. We unveil the role the Gamma variant played in stressing the use of critical care, by developing and calibrating a queueing model that uses data on new onset cases and actual ICU occupancy, symptom’s onset to ICU admission interval, ICU length-of-stay, genomic surveillance, and vaccine effectiveness. Our model shows that infection with the Gamma (P.1) variant led to a 3.5–4.7-fold increase in ICU admission for people younger than 60 years. This situation occurred on top of the already reported higher infection rate of the Gamma variant. Importantly, our results also strongly suggest that the vaccines used in Chile (inactivated mostly, but also an mRNA), were able to curb Gamma variant ICU admission over infections.
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    Single nucleotide variant at the αvβ3 integrin associated to Andes virus infection susceptibility
    (2018) Martinez Valdebenito, Constanza Pamela; Angulo Troncoso, Jenniffer Alexandra; Le Corre Perez, Monique Nicole; Marco Caceres, Claudia Alejandra; Vial, Cecilia; Miquel Poblete, Juan Francisco; Cerda Lorca, Jaime Rodrigo; Mertz, Gregory; Vial, Pablo; Lopez Lastra, Marcelo Andres; Ferres Garrido Marcela Viviana
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    The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling
    (2020) Vera Otárola, Jorge Andrés; Solis, L.; Lowy de la Torre, Fernando; Olguin Araneda, Valeria Alejandra; Angulo Troncoso, Jenniffer Alexandra; Pino, K.; Tischler, N. D.; Otth, C.; Padula, P.; López Lastra, Marcelo Andrés