Browsing by Author "Alarcon, Graciela S."

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    A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group
    (2021) Gomez-Puerta, Jose A.; Pons-Estel, Guillermo J.; Quintana, Rosana; Nieto, Romina; Serrano Morales, Rosa M.; Harvey, Guillermina B.; Wojdyla, Daniel; Scolnik, Marina; Funes Soaje, Carmen; Alba Moreyra, Paula; Novatti, Elisa; Arizpe, Fernando; Berbotto, Guillermo A.; Gonzalez Lucero, Luciana; Porta, Sabrina; Perez, Nicolas; Rodriguez, Anabella M.; Appenzeller, Simone; de Oliveira e Silva Montadon, Ana Carolina; Monticielo, Odirlei Andre; Cavalcanti, Fernando S.; Ribeiro, Francinne Machado; Borba, Eduardo F.; dos Reis-Neto, Edgard Torres; Neira, Oscar; Miguel Chahuan, Jose; Mimica, Milena; Aroca Martinez, Gustavo; Tobon, Gabriel J.; Vasquez, Gloria; Quintana-Lopez, Gerardo; Moreno Alvarez, Mario J.; Angel Saavedra, Miguel; Perez Cristobal, Mario; Fragoso-Loyo, Hilda; Amezcua-Guerra, Luis M.; Gonzalez-Bello, Yelitza C.; Abud-Mendoza, Carlos; Esquivel-Valerio, Jorge A.; Duarte, Margarita; Acosta Colman, Isabel; Mora-Trujillo, Claudia; Reategui-Sokolova, Cristina; Calvo Quiroz, Armando A.; Munoz-Louis, Roberto; Cairoli, Ernesto; Rosas, Iliana; Rebella, Martin; Cardiel, Mario H.; Garcia de la Torre, Ignacio; Catoggio, Luis J.; Alarcon, Graciela S.; Pons-Estel, Bernardo A.
    Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of "Lupus Investigators" in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
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    Factors predictive of thrombotic events in LUMINA, a multi-ethnic cohort of SLE patients (LXXII)
    (OXFORD UNIV PRESS, 2010) Burgos, Paula I.; McGwin, Gerald, Jr.; Reveille, John D.; Vila, Luis M.; Alarcon, Graciela S.
    Method. SLE patients (ACR criteria), age epsilon 16 years, disease duration 5 years at enrolment (T0), African-American, Hispanic (Texan or Puerto Rican) or Caucasian ethnicity, from LUMINA, a longitudinal cohort, were studied. An event was defined as the presence of arterial or venous thrombosis. Time to the first thrombotic event was examined by univariable and multivariable (MV) Cox models adjusting for pertinent baseline clinical and socio-demographic variables.
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    Radiographic Severity of Rheumatoid Arthritis in African Americans: Results From a Multicenter Observational Study
    (WILEY-LISS, 2010) Bridges, S. Louis, Jr.; Causey, Zenoria L.; Burgos, Paula I.; Huynh, B. Quynh N.; Hughes, Laura B.; Danila, Maria I.; van Everdingen, Amalia; Ledbetter, Stephanie; Conn, Doyt L.; Tamhane, Ashutosh; Westfall, Andrew O.; Jonas, Beth L.; Callahan, Leigh F.; Smith, Edwin A.; Brasington, Richard; Moreland, Larry W.; Alarcon, Graciela S.; van der Heijde, Desiree M.
    Objective. To describe radiographic changes in African Americans with rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluations of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry, a multicenter observational study.
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    Therapeutic Guidelines for Latin American Lupus Patients Methodology
    (2018) Cardiel, Mario H.; Soriano, Enrique R.; Dutra de Oliveira Bonfa, Eloisa Silva; Alarcon, Graciela S.; Izcovich, Ariel; Amigo Castaneda, Mary Carmen; Barile-Fabris, Leonor A.; Duarte, Margarita; Espada, Graciela; Garcia, Mercedes A.; Levy, Roger A