Browsing by Author "Akkerhuis, M"
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- ItemDisagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study(2001) Mahaffey, KW; Harrington, RA; Akkerhuis, M; Kleiman, NS; Berdan, LG; Crenshaw, BS; Tardiff, BE; Granger, CB; DeJong, I; Bhapkar, M; Widimsky, P; Corbalon, R; Lee, KL; Deckers, JW; Simoons, ML; Topol, EJ; Califf, RMBackground Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal myocardial infarctions (MIs) reported by site investigators in the international Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial and those adjudicated by a central clinical events committee (CEC) to determine the reasons for differences in event rates.