Browsing by Author "Acevedo-Gallinato, Keryma"

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    Gelastic epilepsy: Beyond hypothalamic hamartomas
    (2015) Uribe-San-Martin, Reinaldo; Ciampia, Ethel; Lawson-Peralta, Balduin; Acevedo-Gallinato, Keryma; Torrealba-Marchant, Gonzalo; Campos-Puebla, Manuel; Godoy-Fernández, Jaime
    Gelasticepilepsyorlaughingseizureshavebeenhistoricallyrelatedtochildrenwithhypothalamichamartomas. Wereportthreeadultpatientswhohadgelasticepilepsy,definedasthepresenceofseizureswithaprominent laughcomponent,includingbrainimaging,surface/invasiveelectroencephalography,positronemissiontomography,andmedical/surgicaloutcomes.Noneofthepatientshadhamartomaorotherhypothalamiclesion.Two patientswereclassifiedashavingrefractoryepilepsy(onehadbiopsy-provenneurocysticercosisandtheother onehippocampalsclerosisandtemporalcorticaldysplasia).ThethirdpatienthadnolesiononMRIandhad completecontrolwithcarbamazepine.Bothlesionalpatientsunderwentresectivesurgery,onewithcomplete seizurecontrolandtheotheronewithpooroutcome.Althoughhypothalamichamartomasshouldalways beruledoutinpatientswithgelasticepilepsy, laughingseizurescanalsoarisefromfrontalandtemporal lobefoci,whichcanbesurgicallyremoved. Inaddition,wepresentthefirstcaseofgelasticepilepsydueto neurocysticercosis.