Browsing by Author "Abarca, Jorge"
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- Item4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo(2012) Sotomayor Zárate, Ramón Eduardo; Quiroz, Gabriel; Araya Gutiérrez, Katherine Angélica; Abarca, Jorge; Ibañez, Maria R.; Montecinos, Alejandro; Guajardo, Carlos; Nuñez, Gabriel; Fierro Huerta, Angélica; Moya, Pablo R.; Iturriaga-Vasquez, Patricio; Gomez-Molina, Cristobal; Gysling Caselli, Katia
- ItemAminochrome induces dopaminergic neuronal dysfunction : a new animal model for Parkinson's disease(2016) Herrera, Andrea; Muñoz, Patricia; Irmgard, Paris; Gysling Caselli, Katia; Abarca, Jorge
- ItemCharacterization of a presymptomatic stage in a Drosophila Parkinson's disease model: Unveiling dopaminergic compensatory mechanisms(2017) Molina-Mateo, Daniela; Fuenzalida Uribe, Nicolás Leonardo; Hidalgo, Sergio; Molina-Fernández, Claudia; Abarca, Jorge; Zárate Canales, Rafaella Victoria; Escandón, Marcela; Figueroa, Reinaldo; Tevy, María Florencia; Campusano Astorga, Jorge Mauricio
- ItemExo70 protects against memory and synaptic impairments following mild traumatic brain injury(2023) Lira, Matias; Abarca, Jorge; Mira, Rodrigo G.; Zamorano, Pedro; Cerpa Nebott, Waldo FranciscoMild traumatic brain injury (mTBI) is damage to the brain due to external forces. It is the most frequent form of brain trauma and a leading cause of disability in young adults. Hippocampal glutamatergic transmission and synaptic plasticity are impaired after mTBI, and NMDA receptors play critical in these functions. The Exocyst is a vesicle tethering complex implicated in the trafficking of glutamate receptors. We have previously shown that Exo70, a critical exocyst's subunit, redistributes in the synapse and increases its interaction with GluN2B in response to mTBI, suggesting a role in the distribution of the GluN2B subunit of NMDARs from synaptic to extrasynaptic membranes. We tested whether Exo70 could prevent NMDAR depletion from the synapse and limit mTBI pathology. To this end, we used a modified Maryland's model of mTBI in mice overexpressing Exo70 in CA1 pyramidal neurons through a lentiviral vector transduction. We showed that after mTBI, the overexpression of Exo70 prevented the cognitive impairment observed in mice infected with a control vector using the Morris' water maze paradigm. Following these findings, mice overexpressing Exo70 showed basal and NMDAR-dependent hippocampal synaptic transmission comparable to sham animals, preventing the deterioration induced by mTBI. Long-term potentiation, abundant synaptic GluN2B-containing NMDARs, and downstream signaling effectors showed that Exo70 overexpression prevented the mTBI-induced alterations. Our findings revealed a crucial role of Exo70 in NMDAR trafficking to the synapse and suggested that the Exocyst complex may be a critical component of the basal machinery that regulates NMDAR distribution in health and disease.
- ItemExposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area(2015) Sotomayor-Zarate, Ramon; Abarca, Jorge; Araya, Katherine A.; Renard, Georgina M.; Andres, Maria E.; Gysling, KatiaA higher vulnerability to drug abuse has been observed in human studies of individuals exposed to chronic or persistent stress, as well as in animal models of drug abuse. Here, we explored the effect of repeated immobilization stress on cocaine-induced increase in dopamine extracellular levels in VTA and its regulation by corticotropin-releasing factor (CRF) and GABA systems.
- ItemRegulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum : in vivo microdialysis studies(1992) Bustos O., Gonzalo; Abarca, Jorge; Forray Claps, María Inés; Gysling Caselli, Katia; Bradberry, Charles W.; Roth, Robert H.
- ItemThe activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels(2017) Ferrada, Carla; Sotomayor Zárate, Ramón Eduardo; Abarca, Jorge; Gysling Caselli, Katia