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Browsing by Author " Corvalán R., Alejandro"

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A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer
(2021) Cordova-Delgado, Miguel; Bravo Castillo, María Loreto; Cumsille, Elisa; Hill Machado, Charlotte Nicole; Pinto, Mauricio P.; Miquel P., Juan Francisco; Rodríguez-Fernández, María; Corvalán R., Alejandro; Garrido S., Marcelo; Owen, Gareth Ivor
Background: Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe fluoropyrimidine toxicity within European populations. However, the frequency of these single nucleotide polymorphisms (SNPs) in the Latin American population is low (< 0.7%). No guidelines have been development for platinum. Herein, we present association between clinical factors and common SNPs in the development of grade 3–4 toxicity. Methods: Retrospectively, 224 clinical records of GC patient were screened, of which 93 patients were incorporated into the study. Eleven SNPs with minor allelic frequency above 5% in GSTP1, ERCC2, ERCC1, TP53, UMPS, SHMT1, MTHFR, ABCC2 and DPYD were assessed. Association between patient clinical characteristics and toxicity was estimated using logistic regression models and classification algorithms. Results; Reported grade ≤ 2 and 3–4 toxicities were 64.6% (61/93) and 34.4% (32/93) respectively. Selected DPYD SNPs were associated with higher toxicity (rs1801265; OR = 4.20; 95% CI = 1.70–10.95, p = 0.002), while others displayed a trend towards lower toxicity (rs1801159; OR = 0.45; 95% CI = 0.19–1.08; p = 0.071). Combination of paired SNPs demonstrated significant associations in DPYD (rs1801265), UMPS (rs1801019), ABCC2 (rs717620) and SHMT1 (rs1979277). Using multivariate logistic regression that combined age, sex, peri-operative chemotherapy, 5-FU regimen, the binary combination of the SNPs DPYD (rs1801265) + ABCC2 (rs717620), and DPYD (rs1801159) displayed the best predictive performance. A nomogram was constructed to assess the risk of developing overall toxicity. Conclusion: Pending further validation, this model could predict chemotherapy associated toxicity and improve GC patient quality of life.
A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
(2020) Pinto Paganini, Mauricio Arturo; Bravo Castillo, Maria Loreto; Sánchez Rojel, César Giovanni; Acevedo, Francisco; Mondaca Contreras, Sebastián Patricio; Ibañez, Carolina; Galindo A., Héctor; Madrid Arenas, Jorge; Nervi Nattero, Bruno; Peña Durán, José Esteban; Torres Montes, Paula Javiera; Owen, Gareth Ivor; Corvalán R., Alejandro; Garrido S., Marcelo; Córdova Delgado, M.; Retamal, I. N.; Muñoz Medel, M.; Durán, D.; Villanueva, F.; Koch, E.; Armisen, R.
A Novel Role for Helicobacter pylori Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells
(2019) Bravo, J.; Diaz, P.; Corvalán R., Alejandro; Quest, A.F.G.
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
(2024) Vacarezza, Cristóbal; Araneda, Julieta; González Hevia, Pamela Andrea; Arteaga, Oscar; Marcelain, Katherine; Castellon, Enrique A.; Periera, Ana; Khoury, Maroun; Müller, Bettina; Lecaros, Juan A.; Salas, Sofia P.; Riquelme Pérez, Arnoldo; Corvalán R., Alejandro; de la Jara, Jorge J.; Ferreccio, Catterina; Goic B., Carolina; Nervi Nattero, Bruno; Roa, Juan C.; Owen, Gareth Ivor
Abstract Introduction Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, the authors put forward a comprehensive analysis of cancer infrastructure, together with a series of suggestions on research orientated political policy. Objectives Provide an update and comment on policy, infrastructure, gender equality, stakeholder participation and new challenges in national oncology. Assess the funding and distribution of cancer investigation. Present actions for the development of oncology research, innovation and patient care. Methods Triangulating objective system metrics of economic, epidemiological, private and public sector resources together with policy analysis, we assessed cancer burden, infrastructure, and investigation. We analyzed governmental and private-sector cancer databases, complemented by interviews with cancer stakeholders. Results Governmental policy and patient advocacy have led to the recognition of cancer burden, a cancer law, and a national cancer plan. Cancer has become the leading cause of death in Chile (59,876 cases and 31,440 cancer deaths in 2022), yet only 0.36% gross domestic product (GDP) is directed to research and development. Inequalities in treatment regimens persist. Prevention policy has lowered tobacco consumption, sugar intake via soft drinks and offered a high coverage of HPV vaccines. A high-quality cancer research community is expanding, and internationally sponsored clinical oncology trials are increasing. Conclusions The cancer law has facilitated advancement in policy. Prevention policies have impacted tobacco and sugar intake, while gender equality and care inequality have entered the public forum. Cancer research is stagnated by the lack of investment. Implementation of a cancer registry and biobanking, reinforcement of prevention strategies, development of human resources, promotion of clinical trial infrastructure and investment in new technologies must be placed as a priority to permit advancements in innovation and equitable cancer care.
A snapshot of cancer in Chile: analytical frameworks for developing a cancer policy
(2015) Jiménez de la Jara, Jorge; Bastías, Gabriel; Ferreccio Readi, Catterina; Moscoso, Cristián; Sagués, Sofía; Cid Pedraza, Camilo; Bronstein, Eduardo; Herrera Riquelme, Cristian Alberto; Nervi, Bruno; Corvalán R., Alejandro; Jiménez de la Jara, Jorge; Bastías, Gabriel; Ferreccio Readi, Catterina; Moscoso, Cristián; Sagués, Sofía; Cid Pedraza, Camilo; Bronstein, Eduardo; Herrera Riquelme, Cristian Alberto; Nervi, Bruno; Corvalán R., Alejandro
A Summary of the 2020 Gastric Cancer Summit at Stanford University
(2020) Huang, R. J.; Koh, H.; Hwang, J. H.; Abnet, C. C.; Alarid-Escudero, F.; Amieva, M. R.; Bruce, M. G.; Camargo, M. C.; Chan, A. T.; Corvalán R., Alejandro; Choi, I. J.; Davis, J. L.; Deapen, D.; Epplein, M.; Greenwald, D. A.; Hamashima, C.; Hur, C.; Inadomi, J. M.; Ji, H. P.; Jung, H. Y.; Lee, E.; Lin, B.; Palaniappan, L. P.; Parsonnet, J.; Peek, R. M.; Piazuelo, M. B.; Rabkin, C. S.; Shah, S. C.; Smith, A.; So, S.; Stoffel, E. M.; Umar, A.; Wilson, K. T.; Woo, Y.; Yeoh, K. G.; Summit Leaders
Angiotensin-(1-9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway
(2020) Sotomayor-Flores, C.; Rivera-Mejias, P.; Vasquez-Trincado, C.; Lopez-Crisosto, C.; Morales, P. E.; Pennanen, C.; Polakovicova, Iva; Roa Strauch, Juan Carlos Enrique; Ocaranza, María Paz; Corvalán R., Alejandro; Aliaga-Tobar, V.; Garcia, L.; Rothermel, B. A.; Maracaja-Coutinho, V.; Ho-Xuan, H.; Meister, G.; Chiong, M.; Parra, V.; Lavandero, S.
Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
(2008) Ferreccio Readi, Catterina; Corvalán R., Alejandro; Margozzini Maira, Paula; Viviani García, Paola; González, Claudia; Aguilera, Ximena; Gravitt, Patti E
Abstract Background Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus Methods The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated. Results Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age. Conclusion Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.
Cohort Profile : The Maule Cohort (MAUCO)
(2020) Ferreccio Readi, Catterina; Huidobro, A.; Cortés Arancibia, Sandra; Bambs S., Claudia; Toro Espinoza, Pablo Esteban; Van De Wyngard, Vanessa; Acevedo Romo, Johanna Patricia; Verdejo Pinochet, Hugo; Cook, María Paz; Castro Gálvez, Pablo Federico; Cruz Olivos, Francisco; Corvalán R., Alejandro; Paredes, F.; Venegas, P.; Oyarzún González, X.; Foerster, C.; Vargas, C.; Koshiol, J.; Araya, J. C.; Quest, A. F.; Kogan, M. J.; Lavandero, S.; MAUCO Study Group; CEDEUS (Chile)
Correction to : MicroRNA‑335‑5p is a potential suppressor of metastasis and invasion in gastric cancer
(2021) Sandoval Bórquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Avino, Gonzalo; Bizama, Carolina; Norero Muñoz, Enrique; Owen, Gareth Ivor; Roa Strauch, Juan Carlos Enrique; Corvalán R., Alejandro
An amendment to this paper has been published and can be accessed via the original article.
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
(2016) Álvarez Aguilera, Carolina Soledad.; Tapia Espinoza, Teresa Marloren; Solís, Luisa.; Corvalán R., Alejandro; Camus Appuhn, Mauricio Gonzalo; Carvallo de Saint Quentin, Pilar; Aravena, Andrés.; Rozenblum, Ester.; Álvarez, Manuel.; Munroe, David.; Maass, Alejandro.
Abstract Background Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer has been proposed as a relevant contribution to breast cancer progression for tumors with no germline mutation. Identifying the genomic alterations taking place in BRCA1 not expressing tumors will lead us to a better understanding of the cellular functions affected in this heterogeneous disease. Moreover, specific genomic alterations may contribute to the identification of potential therapeutic targets and offer a more personalized treatment to breast cancer patients. Methods Forty seven tumors from hereditary breast cancer cases, previously analyzed for BRCA1 expression, and screened for germline BRCA1 and 2 mutations, were analyzed by Array based Comparative Genomic Hybridization (aCGH) using Agilent 4x44K arrays. Overall survival was established for tumors in different clusters using Log-rank (Mantel-Cox) Test. Gene lists obtained from aCGH analysis were analyzed for Gene Ontology enrichment using GOrilla and DAVID tools. Results Genomic profiling of the tumors showed specific alterations associated to BRCA1 or 2 mutation status, and BRCA1 expression in the tumors, affecting relevant cellular processes. Similar cellular functions were found affected in BRCA1 not expressing and BRCA1 or 2 mutated tumors. Hierarchical clustering classified hereditary breast tumors in four major, groups according to the type and amount of genomic alterations, showing one group with a significantly poor overall survival (p = 0.0221). Within this cluster, deletion of PLEKHO1, GDF11, DARC, DAG1 and CD63 may be associated to the worse outcome of the patients. Conclusions These results support the fact that BRCA1 lack of expression in tumors should be used as a marker for BRCAness and to select these patients for synthetic lethality approaches such as treatment with PARP inhibitors. In addition, the identification of specific alterations in breast tumors associated with poor survival, immune response or with a BRCAness phenotype will allow the use of a more personalized treatment in these patients.
Differentially Expressed Oncogenic Pathways Are Associated With Ethnicity Differences in Gastric Cancer
(2016) Corvalán R., Alejandro; Wichmann Pérez, Ignacio Alberto; Artigas, Rocío.
Effects of preparation on catalytic, magnetic and hybrid micromotors on their functional features and application in gastric cancer biomarker detection
(2020) Baez, D. F.; Ramos, G.; Corvalán R., Alejandro; Cordero, M. L.; Bollo, S.; Kogan, M. J.
Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
(2019) Gomaa, Ahmed; Peng, DunFa; Chen, Zhen; Soutto, Mohammed; Abouelezz, Khaled; Corvalán R., Alejandro; El-Rifai, Wael
Epigenetics in the pathogenesis and early detection of gastric cancer
(2013) Corvalán R., Alejandro
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
(2016) Pinto, M.; Sotomayor, P.; Carrasco, G.; Corvalán R., Alejandro; Owen, Gareth Ivor
Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage
(2016) Wichmann Pérez, Ignacio Alberto; Corvalán R., Alejandro; Amigo Donoso, Julio; Owen, Gareth Ivor; Zavala, Kattina.; Hoffmann, Federico G.; Vandewege, Michael W.; Opazo, Juan C.
Expression of RPRM/rprm in the olfactory system of embryonic zebrafish (Danio rerio)
(2018) Stanic, Karen; Quiroz Vallverdu, Alonso Ingmar; Lemus, Carmen G.; Wichmann Pérez, Ignacio Alberto; Corvalán R., Alejandro; Owen, Gareth Ivor; Opazo, Juan C.; Concha, Miguel L.; Amigo Donoso, Julio
Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer
(2017) Graumann, Rebecca; Di Capua, Gabriella A.; Oyarzún Isamitt, Juan Esteban; Vásquez, Marcos A.; Liao, Christine; Brañes Yunusic, Jorge Antonio; Roa, Iván; Casanello Toledo, Paola Cecilia; Corvalán R., Alejandro; Owen, Gareth Ivor; Delgado, Iris; Zangemeister-Wittke, Uwe; Ziegler, Annemarie
Extracellular vesicles through the blood–brain barrier: a review
(2022) Ramos Zaldívar, Héctor M.; Polakovicova, Iva; Salas-Huenuleo, Edison; Corvalán R., Alejandro; Kogan, Marcelo J.; Yefi Rubio, Claudia Pamela; Andía Kohnenkampf, Marcelo Edgardo
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain parenchyma remains poorly understood. Most in vitro models that have evaluated this event have relied on monolayer transwell or microfluidic organ-on-a-chip techniques that do not account for the combined effect of all cellular layers that constitute the BBB at different sites of the Central Nervous System. There has not been direct transcytosis visualization through the BBB in mammals in vivo, and evidence comes from in vivo experiments in zebrafish. Literature is scarce on this topic, and techniques describing the mechanisms of EVs motion through the BBB are inconsistent. This review will focus on in vitro and in vivo methodologies used to evaluate EVs transcytosis, how EVs overcome this fundamental structure, and discuss potential methodological approaches for future analyses to clarify these issues. Understanding how EVs cross the BBB will be essential for their future use as vehicles in pharmacology and therapeutics.

Browsing by Author " Corvalán R., Alejandro"

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