Browsing by Author "Álvarez, Patricia"

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    Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study
    (2024) Vaz Ferreira, Catalina; Caro, Jose; Villarroel del Pino, Luis A.; Muñoz, Sergio; Álvarez, Patricia; Flores, Gerardo; Herrera, Tamara; Toso, Alberto; Toso Milos, Paulina Alejandra; Tapia Illanes, José Luis; NEOCOSUR Neonatal Network
    Objective: To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. Study design: Retrospective, cohort study of infants <32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities. Results: 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49–0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50–0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72–1.71]). No differences between groups were observed in rates of morbidities. Conclusion: Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.
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    Antenatal Exposure to Magnesium Sulphate and Neonatal Outcomes in Very Low Birth Weight Infants: a multicenter study.
    (2023) Ferreira, María Vaz; Caro, José; Villarroel, Luis; Muñoz, Sergio; Álvarez, Patricia; Flores, Gerardo; Herrera, Tamara; Toso Milos, Alberto Antonio; Toso Milos Paulina Alejandra; Tapia, José
    Objective: To explore the association between antenatal magnesium sulphate ( MgSO4 ), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. Study design: Retrospective, cohort study of infants < 32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities. Results: 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a signicantly decreased death rate after admission (aOR 0.59 [95% CI, 0.46–0.74]) and severe IVH/ death (aOR 0.63 [95% CI, 0.490.83]). No signicant reduction in severe IVH was observed (aOR 0.89 [95% CI, 0.63–1.25]). No differences between groups were observed in rates of morbidities. Conclusion: Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.