Inflammatory markers in the tears of patients with ocular surface disease

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dc.contributor.authorAcera, Arantxa
dc.contributor.authorRocha, German
dc.contributor.authorVecino, Elena
dc.contributor.authorLema, Isabel
dc.contributor.authorDuran, Juan A.
dc.date.accessioned2024-01-10T13:13:51Z
dc.date.available2024-01-10T13:13:51Z
dc.date.issued2008
dc.description.abstractPurpose: To determine the concentration of interleukins (IL-1 beta and - 6) and matrix metalloproteinase 9 (pro-MMP-9) in the tears of patients with different ocular surface diseases and to examine the possible relationship between the disorders and molecular inflammation. Methods: 77 patients diagnosed as having different ocular surface disorders and 18 normal control subjects were studied. Patients were routinely examined and separated into 5 groups: (1) control, (2) blepharitis, (3) ocular allergic disease, (4) dry eye and (5) conjunctivochalasis. Ten microliters of tears were collected by a Weck cell sponge. The concentrations of IL-1 beta, IL-6 and proMMP-9 were measured by enzyme-linked immunosorbent assay, and the MMP-9 activity was evaluated with gelatin zymography. Results: Levels of IL-1 beta and IL-6 in tear fluid were significantly higher in conjunctivochalasis (p = 0.0062 and p = 0.0134) than in the control group. Pro-MMP-9 levels were significantly elevated in blepharitis (p = 0.013), in allergic eye disease, in dry eye and in conjunctivochalasis (all p < 0.001),in comparison to controls. Conclusions: Pro-MMP-9 levels in tears are elevated in all of the studied pathologies especially in ocular allergy and conjunctivochalasis. However, IL-1 beta and
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1159/000150445
dc.identifier.eissn1423-0259
dc.identifier.issn0030-3747
dc.identifier.pubmedidMEDLINE:18688174
dc.identifier.urihttps://doi.org/10.1159/000150445
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78346
dc.identifier.wosidWOS:000259725100005
dc.information.autorucMedicina;Rocha G;S/I;102104
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final321
dc.pagina.inicio315
dc.publisherKARGER
dc.revistaOPHTHALMIC RESEARCH
dc.rightsacceso restringido
dc.subjecttear fluid
dc.subjectinterleukins
dc.subjectmatrix metalloproteinase
dc.subjectocular surface diseases
dc.subjectDRY-EYE
dc.subjectMEIBOMIAN GLAND
dc.subjectEXPRESSION
dc.subjectCONJUNCTIVOCHALASIS
dc.subjectINTERLEUKIN-6
dc.subjectFIBROBLASTS
dc.subjectCYTOKINES
dc.subjectMMP-1
dc.subjectCELLS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInflammatory markers in the tears of patients with ocular surface disease
dc.typeartículo
dc.volumen40
sipa.codpersvinculados102104
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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