A tool to assist the study of specific features at protein binding sites

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dc.article.numberi250-1
dc.catalogadoraba
dc.contributor.authorSantander, V.
dc.contributor.authorPortales, M. A.
dc.contributor.authorMelo Ledermann, Francisco Javier
dc.date.accessioned2025-02-06T18:57:59Z
dc.date.available2025-02-06T18:57:59Z
dc.date.issued2003
dc.description.abstractThe Protein Data Bank contains a large amount of proteins that have been solved with small ligands bound to them. This constitutes a rich source of information for the study of the specific requirements of protein sites to bind small molecules with a favorable free energy. The specific atomic composition and three-dimensional geometric restraints of protein binding sites for different ligands could be easily obtained from there. The development of accurate binding site descriptors in proteins constitutes a valuable tool to assist in the large-scale prediction and annotation of protein function in whole genomes. In this work, an integrated database containing some processed and calculated protein/ligand information is described. It is expected that this database will constitute a useful tool for people working in the prediction of protein function from its structure. The database is accessible from the Internet through a web server located at: http://protein.bio.puc.cl
dc.fuente.origenSIPA
dc.identifier.doi10.1093/bioinformatics/btg1034
dc.identifier.eissn1367-4811
dc.identifier.issn1367-4803
dc.identifier.scopusid2-s2.0-4944246166
dc.identifier.urihttps://doi.org/10.1093/bioinformatics/btg1034
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102170
dc.identifier.wosidWOS:000207434200036
dc.information.autorucFacultad de Ciencias Biológicas; Melo Ledermann, Francisco Javier; 0000-0002-0424-5991; 82342
dc.issue.numeroSuppl. 1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaBioinformatics (Oxford, England)
dc.rightsacceso restringido
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleA tool to assist the study of specific features at protein binding sites
dc.typeartículo
dc.volumen19
sipa.codpersvinculados82342
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