Natriuretic peptide type-B can be a marker of reperfusion in patients with pulmonary thromboembolism subjected to invasive treatment

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dc.contributor.authorAndresen, Max
dc.contributor.authorGonzalez, Alejandro
dc.contributor.authorMercado, Marcelo
dc.contributor.authorDiaz, Orlando
dc.contributor.authorMeneses, Luis
dc.contributor.authorFava, Mario
dc.contributor.authorCordova, Samuel
dc.contributor.authorCastro, Ricardo
dc.date.accessioned2025-01-20T23:58:31Z
dc.date.available2025-01-20T23:58:31Z
dc.date.issued2012
dc.description.abstractThis study was intended to investigate changes in cardiac biomarkers and pulmonary hemodynamic effects of invasive treatment in patients with intermediate-risk (hemodynamic stability with evidence of right ventricle dysfunction and/or myocardial injury) pulmonary embolism. Also, to also evaluate if natriuretic peptide type-B (NT-proBNP) plasma levels are associated with right ventricle function and pulmonary arterial pressures. Interventional study: Fourteen normotensive adult patients with acute and radiologically massive pulmonary embolism plus positive biomarkers and evidences of right ventricle dysfunction underwent invasive pulmonary angiography for invasive treatment consisting on mechanical thrombus fragmentation and catheter-directed intrathrombus thrombolysis. Angiography was repeated after 12-24 h to reevaluate perfusion status. Plasma biomarkers were monitored before and 8-h after intervention. Biomarkers were initially elevated in all patients. Eleven patients (78.6%) exhibited significant angiographic reperfusion. NT-proBNP and mean pulmonary arterial pressure decreased significantly in all of them [3693 (1803, 8862) to 1951 (1309, 7918) pg/ml; P = 0.008) and 40.0 (24.0, 46.0) to 22.0 (14.0, 27.0) mmHg; P = 0.003, respectively]. No significant variation was observed in troponin-T levels. In patients with high-risk pulmonary embolism, NT-proBNP plasma levels experience rapid and significant reduction after successful invasive treatment. In pulmonary embolism, serial measurements of NT-proBNP could be useful as a tracking tool to assess the success or failure of the thrombolytic treatment.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10554-011-9857-7
dc.identifier.eissn1573-0743
dc.identifier.issn1569-5794
dc.identifier.urihttps://doi.org/10.1007/s10554-011-9857-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95254
dc.identifier.wosidWOS:000302815500025
dc.issue.numero3
dc.language.isoen
dc.pagina.final666
dc.pagina.inicio659
dc.revistaInternational journal of cardiovascular imaging
dc.rightsacceso restringido
dc.subjectPulmonary embolism
dc.subjectAngiography
dc.subjectThrombolysis
dc.subjectBiomarkers
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNatriuretic peptide type-B can be a marker of reperfusion in patients with pulmonary thromboembolism subjected to invasive treatment
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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