Browsing by Author "Arab Verdugo, Juan Pablo"

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    The Cannabinoid System as a Potential Novel Target for Alcohol‐Associated Liver Disease: A Propensity‐Matched Cohort Study
    (2025) Fakhoury, Butros; Jahagirdar, Vinay; Rama, Kaanthi; Hudson, David; Wang, Wei; Diaz Piga, Luis Antonio; Arab Verdugo, Juan Pablo
    Background: Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality, yet effectivetherapeutic options remain limited. Preclinical data suggest that modulation of the hepatic endocannabinoid system, particularlyvia cannabidiol (CBD), may reduce alcohol-induced liver injury. Due to CBD's limited clinical use, we sought to evaluate the as-sociation between cannabis use and ALD risk among patients with alcohol use disorder (AUD).Methods: Using the TriNetX US Collaborative Network, we identified adult patients with AUD between 2010 and 2022. Threecohorts were constructed: cannabis use disorder (CUD), cannabis users without cannabis abuse or dependence (CU) and non-cannabis users (non- CU). Outcomes included ALD, hepatic decompensation and composite all-cause mortality over 3 years.Incidence and hazard ratios were calculated using Kaplan–Meier analysis and Cox regression.Results: After matching, 33 114 patients were included in each of the CUD and non- CU groups. Compared to non- CU, CUD wasassociated with a lower risk of ALD (HR 0.60, 95% CI 0.53–0.67; p < 0.001), hepatic decompensation (HR 0.83, 95% CI 0.73–0.95;p =0.005) and all-cause mortality (HR 0.86, 95% CI 0.80–0.94; p < 0.001) among individuals with AUD. Although CU was asso-ciated with lower risks of ALD, its risks of hepatic decompensation and all-cause mortality were similar to those of the non- CUcohort with AUD.